IL36RN polyclonal antibody

IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NFκB and AP-1, thereby promoting host response to injury or infection. The IL-1 superfamily is comprised of several ligands and receptors. IL-1F5, also known as IL-1δ, IL-1 like protein 1 (IL-1L1), IL-1HY1, IL-1ra (receptor antagonist) homolog 1 or IL-1 related protein 3 (IL-1rp3), is a secreted ligand belonging to this superfamily. IL-1F5 is expressed in monocytes and macrophages and is activated by endotoxins. It shares 47% sequence identity with IL-1ra and similarly lacks the loop between the fourth and fifth ∫-strands. IL-1F5 acts as an antagonist, inhibiting the IL-1F9 activation of NFκB. Similar to other family members, IL-1F5 can be regulated by bacterial lipopolysaccharide (LPS).