DDX24 polyclonal antibody

DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis and cellular growth and division. DDX24 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 24) is an 859 amino acid protein that contains one helicase C-terminal domain and one helicase ATP-binding domain. Expressed ubiquitously with highest levels in brain and heart, DDX24 functions as an ATP-dependent RNA helicase that is subject to DNA damage-dependent phosphorylation. Human DDX24 shares 79% sequence similarity with its mouse counterpart, suggesting a conserved role between species.