STXBP1 polyclonal antibody

Munc18-1 belongs to the Munc18 protein family that also includes Munc18-2 and Munc18-3. These proteins are highly conserved at the amino acid sequence level and play a critical role in membrane fusion. Munc18 proteins control SNARE complex formation and interact with syntaxin. In Munc18-1 knockout mice, neurotransmitter release is completely abolished. In addition, Munc18-1 acts as a molecular chaperone for syntaxin-1, allowing for formation of the SNARE complex at the plasma membrane. Munc18-1 also acts as a regulator of vesicle docking during exocytosis.