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Bioworld

SKU(재고 관리 코드):MB66178

CD105 monoclonal antibody

CD105 monoclonal antibody

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Reactivity

CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways . CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated CD105/endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in
CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure . The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer .

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