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Bioworld

SKU(재고 관리 코드):MB66225

Beta-catenin monoclonal antibody

Beta-catenin monoclonal antibody

Size
Host
Reactivity

β-catenin is a key downstream effector in the Wnt signaling pathway . It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis . CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 . Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines

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