CARD8 polyclonal antibody

The MAGUK family includes several mammalian proteins, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3), and the caspase-associated recruitment domain (CARD) proteins, all of which are related to the Drosophila tumor suppressor discs-large (dlg) gene product. CARD 8, also designated DACAR, NDPP1, TUCAN or CARDINAL, is a 431 amino acid protein that is expressed in the lung, ovary, testis, and placenta. It regulates cellular responses controlled by NF-˚ B activation and may play a key role in apoptosis and chronic inflammatory disorders. CARD 8 binds to caspase-1 and negatively regulates its activity.