NCK1 polyclonal antibody

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as R and PDGFRB, or their cellular substrates. Maintains low EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.