ACTR1A polyclonal antibody

The dynactin complex is a macromolecular complex that consists of 10-11 distinct subunits. This complex is critical for the function of dynein, a molecular motor protein. Dynactin plays a role in ER to Golgi transport, spindle formation, chromosome movement, axon guidance, nuclear positioning and the centripetal movement of lysosomes and endosomes. Centractin is a subunit of the dynactin complex that exists in multiple isoforms. The α isoform, also known as actin-related protein 1 homolog A (Arp1) and previously referred to as centractin, is the most abundant isoform in the dynactin complex. The β isoform, also known as actin-related protein 1 homolog B, shares 90% identity with the α isoform. The two isoforms, α and β, are expressed at a ratio of 15:1 respectively. The backbone filament structure of the dynactin complex (important for the arrangement of other complex proteins) is composed of 9-11 subunits of α/β-centractin.