BTRC polyclonal antibody

ß-TrCP (beta-tranducin repeats containing protein), also designated E3RSIkB or FWD1, and HOS (homologous to Slimb) are F-box proteins that function as substrate recognition subunits of ubiquitin ligases. HOS and ß-TrCP differ in their amino terminal regions, but exhibit high homology within the F-box and WD40 repeat-containing regions. ß-TrCP mediates ubiquitin/proteasome-dependent degradation of CD4 and ubiquitination of various proteins including IkB and ß-catenin. HOS has also been shown to regulate the degradation of IkB and ß-catenin in a similar manner.