RBM22 polyclonal antibody

RBM22, also designated Zinc finger CCCH domain-containing protein 16, is a highly conserved RNA binding protein that is predominantly expressed in spleen and is localized to the nucleus. With a RRM (RNA recognition motif domain) and a C3H1-type zinc finger, RBM22 is primarily involved in pre-mRNA splicing. In the presence of RBM22, cytosolic ALG-2 (Apoptosis Linked Gene 2) translocates to the nucleus, suggesting a functional interaction between the two proteins. Homologs of RBM22 are essential proteins in the regulation of alternative splicing in the cell cycle, zebrafish development and Drosophilia heart development.