Human TRPC1 protein is a 793 amino acid cation channel that is expressed in fetal and adult brain, and adult heart, testis and ovary, where it may influence store-operated Ca2+ entry as a component of capacitative calcium entry (CCE) complexes. The activation of store-mediated Ca2+ entry in human cells occurs through the association between inositol 1,4,5-trisphosphate receptors and TRPC1.
