SKIV2L2  polyclonal antibody

SKIV2L2 (superkiller viralicidic activity 2-like 2) is a 1,042 amino acid protein that belongs to the helicase family and the SKI2 subfamily. The SKIV2L2 protein localizes to nucleus, contains one helicase ATP-binding domain and one helicase C-terminal domain. SKIV2L2 is identified in the spliceosome C complex and may be involved in pre-mRNA splicing. SKIV2L2 is associated with the RNA exosome complex and involved in the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA. The SKIV2L2 gene is conserved in chimpanzee, canine, bovine, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C. elegans, S. pombe, S. cerevisiae, K. lactis, E. gossypii, M. grisea, N. crassa, A. thaliana and rice, and maps to human chromosome 5q11.2. A mutation in SKIV2L2 in zebrafish causes defects in cell proliferation, suggesting that SKIV2L2 plays a role in regulating melanoblast proliferation during early stages of melanocyte regeneration.