RUVBL1 polyclonal antibody

Pontin 52 is nuclear matrix protein that is primarily expressed in the nucleus and is also present in the cytoplasm. Pontin 52 is expressed in the nucleoplasm of whole cells, but is not present in the nucleoli. Pontin 52 is also designated RUVBL1, for E. coli RuvB-like 1 protein, or NMP 238, and is the human homolog of rat TIP49. Pontin 52 contains an ATPase/helicase motif and may represent a class of cofactors recruited by transcriptional activation domains that function in diverse pathways. For instance, in vivo, Pontin 52 is complexed with Myc and Reptin 52, which is a Pontin 52 related protein also designated RUVBL2. The interaction of Pontin 52 with Myc is dependent upon a Myc domain essential for oncogenic activity, suggesting that functional Pontin 52 is an essential mediator of Myc oncogenic transformation. The gene encoding human Pontin 52 maps to chromosome 3q21.