GNMT polyclonal antibody

Glycine N-methyltransferase (GNMT) is a 295 amino acid protein that catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). This process indicates that GNMT probably plays a crucial role in the regulation of tissue concentration of AdoMet and in the metabolism of methionine. Originally identified as a methyl donor, AdoMet is now considered a key metabolite that regulates hepatocyte growth, death and differentiation. Biosynthesis of AdoMet occurs in all mammalian cells as the first step in methionine catabolism in a reaction catalyzed by methionine adenosyltransferase (MAT). Decreased hepatic AdoMet biosynthesis is a consequence of all forms of chronic liver injury. In chronic liver AdoMet deficiency, the liver is predisposed to further injury and can develop spontaneous steatohepatitis and hepatocellular carcinoma. However, impaired AdoMet metabolism, which occurs in patients with mutations of GNMT, can also lead to liver injury.