TMED10 polyclonal antibody

TMP21 (21 kDa transmembrane-trafficking protein), also known as TMED10 (transmembrane emp24 domain-containing protein 10), Tmp-21, S31I125, S31III125, p23 or p24∂, is a member of the EMP24/GP25L/p24 cargo family of proteins that regulates vesicular trafficking in the early secretory pathway. TMP21 is a ubiquitously expressed single-pass type I membrane protein localizing to the Golgi cisternae and the plasma membrane. It contains one GOLD (Golgi dynamics) domain and participates in protein transport and quality control between the endoplasmic reticulum (ER) and the Golgi complex. In addition, TMP21 is a component of the heteromeric secretase complex (or Presenilin complex) and functions to regulate the ©-secretase activity. Two isoforms, namely TMP21-I and TMP21-II, exist for this protein.