| TARGET | |
|---|---|
| SYNONYMS |
PD-L1; CD274; B7-H1; PDCD1L1; PDCD1LG1 |
| HOST SPECIES |
Rabbit |
| DESCRIPTION |
Anti-PD-L1 antibody(DM123); Rabbit mAb |
| DELIVERY |
In Stock |
| UNIPROT ID |
Q9NZQ7 |
| IGG TYPE |
Rabbit IgG |
| CLONALITY |
Monoclonal |
| REACTIVITY |
Human |
| APPLICATIONS |
ELISA; Flow Cyt |
| RECOMMENDED DILUTIONS |
ELISA 1:5000-10000; Flow Cyt 1:100 |
| PURIFICATION |
Purified from cell culture supernatant by affinity chromatography |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells; such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue; this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments; this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies; including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):DME100123
Anti-PD-L1 antibody(DM123), Rabbit mAb
Anti-PD-L1 antibody(DM123), Rabbit mAb
PRODUCT DATA
IMAGES
Figure 1. ELISA plate pre-coated by 1 μg/ml (100 μl/well) Human PD-L1 protein, mFc His tagged protein (PME100023) can bind Rabbit anti-PD-L1 monoclonal antibody (clone: DM123) in a linear range of 0.1-15 ng/ml.
Figure 2. Flow cytometry analysis with Anti-PD-L1 (DM123) on Expi293 cells transfected with human PD-L1 (Blue histogram) or Expi293 transfected with irrelevant protein(Red histogram).
