| TARGET | |
|---|---|
| SYNONYMS |
IL-1; IL1-BETA; IL1F2 |
| HOST SPECIES |
Rabbit |
| DESCRIPTION |
Anti-IL1B antibody(DMC271); IgG1 Chimeric mAb |
| DELIVERY |
In Stock |
| UNIPROT ID |
P01584 |
| IGG TYPE |
Rabbit:Human Fc chimeric IgG1 |
| CLONALITY |
Monoclonal |
| REACTIVITY |
Human |
| APPLICATIONS |
Flow Cyt |
| RECOMMENDED DILUTIONS |
Flow Cyt 1:100 |
| PURIFICATION |
Purified from cell culture supernatant by affinity chromatography |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein; which is proteolytically processed to its active form by caspase 1 (CASP1:ICE). This cytokine is an important mediator of the inflammatory response; and is involved in a variety of cellular activities; including cell proliferation; differentiation; and apoptosis. The induction of cyclooxygenase-2 (PTGS2:COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly; IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent; a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):DMC100271
Anti-IL1B antibody(DMC271), IgG1 Chimeric mAb
Anti-IL1B antibody(DMC271), IgG1 Chimeric mAb
PRODUCT DATA
IMAGES
Figure 1. Flow cytometry analysis with Anti-IL1B (DMC271) on Expi293 cells transfected with human IL1B (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
