PRODUCT DATA
| TARGET | |
|---|---|
| SYNONYMS |
DTR; DTS; DTSF; HEGFL |
| HOST SPECIES |
Rabbit |
| DESCRIPTION |
Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb |
| DELIVERY |
In Stock |
| UNIPROT ID |
Q99075 |
| IGG TYPE |
Rabbit:Human Fc chimeric IgG1 |
| CLONALITY |
Monoclonal |
| REACTIVITY |
Human |
| APPLICATIONS |
Flow Cyt |
| RECOMMENDED DILUTIONS |
Flow Cyt 1:100 |
| PURIFICATION |
Purified from cell culture supernatant by affinity chromatography |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
Growth factor that mediates its effects via EGFR; ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts; but not endothelial cells. It is able to bind EGF receptor:EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB:Swiss-Prot Function] |
| USAGE |
Research use only |
IMAGES
Figure 1. Flow cytometry analysis with Anti-HBEGF(DMC500) on Expi293 cells transfected with human HBEGF (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
