PRODUCT DATA
| TARGET | |
|---|---|
| SYNONYMS |
CD221; IGFIR; IGFR; JTK13 |
| HOST SPECIES |
Rabbit |
| DESCRIPTION |
Anti-IGF1R antibody(DMC684); IgG1 Chimeric mAb |
| DELIVERY |
In Stock |
| UNIPROT ID |
P08069; C9J5X1 |
| IGG TYPE |
Rabbit:Human Fc chimeric IgG1 |
| CLONALITY |
Monoclonal |
| REACTIVITY |
Human |
| APPLICATIONS |
Flow Cyt |
| RECOMMENDED DILUTIONS |
Flow Cyt 1:100 |
| PURIFICATION |
Purified from cell culture supernatant by affinity chromatography |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq; May 2014] |
| USAGE |
Research use only |
IMAGES
DMC100684
Figure 1. IGF1R protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-IGF1R (DMC684) on Expi293 cells transfected with human IGF1R (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).
