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Dima Biotech

PME100213

Human CRLF2 Protein, His Tag

Human CRLF2 Protein, His Tag

Size
PRODUCT DATA
TARGET

SYNONYMS

CRL2;TSLPR;CRLF2Y
DESCRIPTION

Recombinant Human CRLF2 Protein with C-terminal 6XHis tag
DELIVERY

In Stock
UNIPROT ID

Q9HC73
EXPRESSION HOST

HEK293
TAG

C-6×His Tag
MOLECULAR CHARACTERIZATION

CRLF2(Gln23-Lys231) 6×His tag
MOLECULAR WEIGHT

The protein has a predicted molecular mass of 25.0 kDa after removal of the signal peptide. The apparent molecular mass of CRLF2-His is approximately 25-55 kDa due to glycosylation.
PURITY

The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
FORMULATION & RECONSTITUTION

Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
STORAGE & SHIPPING

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
BACKGROUND

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
USAGE

Research use only
IMAGES

sp-PME100213 CRLF2 Fig.1 SDS PAGE 1
Figure 1.Human CRLF2 Protein, His Tag on SDS-PAGE under reducing condition.

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