| TARGET | |
|---|---|
| SYNONYMS |
P2X7 |
| DESCRIPTION |
Human P2RX7 full length protein-synthetic nanodisc |
| DELIVERY |
3-4 weeks |
| UNIPROT ID |
Q99572 |
| EXPRESSION HOST |
HEK293 |
| PROTEIN FAMILIES |
Druggable Genome, Ion Channels: ATP Receptors, Transmembrane |
| PROTEIN PATHWAYS |
Calcium signaling pathway, Neuroactive ligand-receptor interaction |
| MOLECULAR WEIGHT |
The human full length P2RX7 protein has a MW of 68.4 kDa |
| FORMULATION & RECONSTITUTION |
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):FLP100049
Human P2RX7 full length protein-synthetic nanodisc
Human P2RX7 full length protein-synthetic nanodisc
PRODUCT DATA
IMAGES
Figure1. Elisa plates were pre-coated with Flag Tag P2RX7-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with P2RX7-Nanodisc is 5.349ng/ml.
Figure2. Human P2RX7-Nanodisc, Flag Tag on SDS-PAGE
