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Dima Biotech

FLP100053

Human CXCR3 full length protein-synthetic nanodisc

Human CXCR3 full length protein-synthetic nanodisc

Size
PRODUCT DATA
TARGET

SYNONYMS

CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R; Mig-R; MigR
DESCRIPTION

Human CXCR3 full length protein-synthetic nanodisc
DELIVERY

3-4 weeks
UNIPROT ID

P49682
EXPRESSION HOST

HEK293
PROTEIN FAMILIES

Druggable Genome, GPCR, Transmembrane
PROTEIN PATHWAYS

Chemokine signaling pathway, Cytokine-cytokine receptor interaction
MOLECULAR WEIGHT

The human full length CXCR3 protein has a MW of 40.5 kDa
FORMULATION & RECONSTITUTION

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
STORAGE & SHIPPING

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
BACKGROUND

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
USAGE

Research use only
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