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Dima Biotech

FLP100092

Human GNRHR full length protein-synthetic nanodisc

Human GNRHR full length protein-synthetic nanodisc

Size
PRODUCT DATA
TARGET

SYNONYMS

GNRHR1; GRHR; HH7; LHRHR; LRHR
DESCRIPTION

Human GNRHR full length protein-synthetic nanodisc
DELIVERY

3-4 weeks
UNIPROT ID

P30968
EXPRESSION HOST

HEK293
PROTEIN FAMILIES

Druggable Genome, GPCR, Transmembrane
PROTEIN PATHWAYS

GnRH signaling pathway, Neuroactive ligand-receptor interaction
MOLECULAR WEIGHT

The human full length GNRHR protein has a MW of 37.6 kDa
FORMULATION & RECONSTITUTION

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
STORAGE & SHIPPING

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
BACKGROUND

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
USAGE

Research use only
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