| TARGET | |
|---|---|
| SYNONYMS |
GLUR2; GPRC1B; mGlu2; MGLUR2 |
| DESCRIPTION |
Human GRM2 full length protein-synthetic nanodisc |
| DELIVERY |
In Stock |
| UNIPROT ID |
Q14416 |
| EXPRESSION HOST |
HEK293 |
| PROTEIN FAMILIES |
Druggable Genome, GPCR, Transmembrane |
| PROTEIN PATHWAYS |
Neuroactive ligand-receptor interaction |
| MOLECULAR WEIGHT |
The human full length GRM2 protein has a MW of 95.6 kDa |
| FORMULATION & RECONSTITUTION |
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):FLP100135
Human GRM2 full length protein-synthetic nanodisc
Human GRM2 full length protein-synthetic nanodisc
가격·납기 및 기술자료를 확인해 드립니다.
제품 규격과 수량을 선택한 후 견적을 요청해 주세요. 대체품 검토와 SDS·COA·데이터시트 요청도 함께 접수할 수 있습니다.
이 제품 견적 요청PRODUCT DATA
IMAGES
Figure1. Elisa plates were pre-coated with Flag Tag GRM2-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with GRM2-Nanodisc is 2.794ng/ml.
Figure2. Human GRM2-Nanodisc, Flag Tag on SDS-PAGE
