| TARGET | |
|---|---|
| SYNONYMS |
MELIOS; SLE1; SLEB1; TIL3 |
| DESCRIPTION |
Human TLR5 full length protein-synthetic nanodisc |
| DELIVERY |
In Stock |
| UNIPROT ID |
O60602 |
| EXPRESSION HOST |
HEK293 |
| PROTEIN FAMILIES |
Druggable Genome, Transmembrane |
| PROTEIN PATHWAYS |
Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway |
| MOLECULAR WEIGHT |
The human full length TLR5 protein has a MW of 97.8 kDa |
| FORMULATION & RECONSTITUTION |
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):FLP100143
Human TLR5 full length protein-synthetic nanodisc
Human TLR5 full length protein-synthetic nanodisc
PRODUCT DATA
IMAGES
Figure1. Elisa plates were pre-coated with Flag Tag TLR5-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with TLR5-Nanodisc is 4.191ng/ml.
Figure2. Human TLR5-Nanodisc, Flag Tag on SDS-PAGE
