anti- Cyclin D1 antibody

Our Anti-Cyclin D1 Antibody, available in a 100µg size, is an indispensable tool for researchers exploring cell cycle regulation and proliferation. Cyclin D1, a member of the Cyclin D family, plays a critical role in controlling the progression of the cell cycle.

Understanding the functions and interactions of Cyclin D1 is essential for unraveling its contributions to normal cell growth and proliferation, as well as its implications in cancer and other diseases. Our antibody has been rigorously validated for specificity and sensitivity, ensuring precise and reproducible results in your experiments.

Its compact size allows for versatility in applications, whether you're conducting Western blotting, immunohistochemistry, or cell cycle studies. Trust in the quality of our Anti-Cyclin D1 Antibody to accelerate your scientific investigations and contribute to advancements in cell biology and cancer research.

Product Name

Cyclin D1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

IMMUNOGEN INFORMATION

Immunogen

cyclin D1

Synonyms

B cell lymphoma 1 protein, CCND1, cyclin D1, D11S287E, G1/S specific cyclin D1, PRAD1, PRAD1 oncogene, U21B31

Observed MW

36 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P24385

IMAGES

Immunohistochemistry of paraffin-embedded human esophagus using FNab10467(cyclin D1 antibody) at dilution of 1:100

various lysates were subjected to SDS PAGE followed by western blot with FNab10467(Cyclin D1 Antibody) at dilution of 1:1000