NFκB-p105/p50(Phospho Ser337) Polyclonal Antibody

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines| oxidant-free radicals| ultraviolet irradiation| and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof

The NF-κB p105/p50 Phospho-Ser337 Polyclonal Antibody, manufactured by Dana Biosciences, is a highly specific and sensitive tool for the detection of phosphorylated NF-κB p105/p50 protein in various biological samples. This antibody is designed to recognize and bind to the phosphorylated serine 337 residue of the NF-κB p105/p50 protein, which is a key regulatory site for the activation of NF-κB signaling pathway.

The NF-κB signaling pathway plays a critical role in the regulation of immune response, inflammation, cell survival, and proliferation. Dysregulation of this pathway has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory diseases. Therefore, the NF-κB p105/p50 Phospho-Ser337 Polyclonal Antibody is a valuable tool for researchers studying the NF-κB signaling pathway and its role in disease pathogenesis.

This antibody is produced using high-quality materials and advanced manufacturing techniques to ensure consistent and reliable performance. It has been validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. The NF-κB p105/p50 Phospho-Ser337 Polyclonal Antibody is available in a convenient size of 100 µg and is supplied in a liquid form for easy handling and storage.

In summary, the NF-κB p105/p50 Phospho-Ser337 Polyclonal Antibody is a highly specific and sensitive tool for the detection of phosphorylated NF-κB p105/p50 protein. It is a valuable resource for researchers studying the NF-κB signaling pathway and its role in disease pathogenesis. With its consistent and reliable performance, this antibody is an essential tool for any laboratory conducting research in this field.