NM23A Rabbit Polyclonal Antibody

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

The NM23A Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of NM23A protein expression in various biological samples. This antibody has been rigorously tested and validated for its superior performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications.

The NM23A protein, also known as NME1, is a nucleoside diphosphate kinase that plays a crucial role in cellular processes such as DNA replication, signal transduction, and metastasis suppression. It is widely expressed in various tissues and has been implicated in numerous physiological and pathological conditions.

This rabbit polyclonal antibody has been meticulously developed using advanced immunization techniques and affinity purification methods to ensure high specificity and sensitivity. It exhibits minimal cross-reactivity with other NM23 family members, making it an ideal choice for specific detection of NM23A protein.

The NM23A Rabbit Polyclonal Antibody offers exceptional performance in IHC, enabling precise localization and visualization of NM23A protein expression in tissue sections. It provides reliable and reproducible results, allowing researchers to accurately assess the distribution and abundance of NM23A in different tissues and disease states.

Furthermore, this antibody is highly suitable for IF applications, enabling the visualization of NM23A protein in cultured cells and tissue sections. Its excellent sensitivity and specificity ensure clear and distinct staining patterns, facilitating the study of NM23A localization and dynamics in cellular processes.

In addition, the NM23A Rabbit Polyclonal Antibody demonstrates outstanding performance in western blotting, enabling the detection and quantification of NM23A protein in cell lysates and tissue extracts. It exhibits high sensitivity, detecting even low levels of NM23A protein, and provides sharp and specific bands, ensuring accurate analysis and interpretation of results.

Overall, the NM23A Rabbit Polyclonal Antibody is a reliable and versatile tool for researchers studying NM23A protein expression and its functional implications. Its exceptional performance in IHC, IF, and western blotting applications makes it an invaluable asset in various fields, including cancer research, developmental biology, and signal transduction studies.