NOTCH4 (Cleaved-Val1467) Rabbit Polyclonal Antibody

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats| and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular| renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants| at least one of which

The NOTCH4 (CLEAVED-VAL1467) Rabbit Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of NOTCH4 protein in various biological samples. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring exceptional sensitivity and specificity.

The NOTCH4 protein plays a crucial role in various cellular processes, including cell differentiation, proliferation, and apoptosis. By targeting the cleaved form of NOTCH4 at Val1467, this antibody enables researchers to investigate the activation and signaling pathways associated with this protein.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other NOTCH family members, ensuring accurate and reliable results.

With its high affinity and specificity, the NOTCH4 (CLEAVED-VAL1467) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying the role of NOTCH4 in various biological processes. Its exceptional performance and reliability make it an ideal choice for both basic research and clinical applications.