• AMPK alpha 2 Antibody / PRKAA2, 0.4ml
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NSJ Bioreagents

F50381-0.4ML

AMPK alpha 2 Antibody / PRKAA2, 0.4ml

AMPK alpha 2 Antibody / PRKAA2, 0.4ml

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The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Specifications

Catalog No F50381-0.4ML
Family Primary antibody
Qty 0.4ml
Formulation In 1X PBS, pH 7.4, with 0.09% sodium azide
Format Purified
Host Animal Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Species Reactivity Human
Predicted Species Reactivity Mouse,Rat
Application WB, IHC, ELISA
Application Details Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
Application Note Titration of the AMPK alpha 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Status Available
PDF Link Product Data Sheet (PDF)
Limitation This AMPK alpha 2 antibody is available for research use only.
Uniprot # P54646
Purity Purified
Immunogen A portion of amino acids 453-483 from the human protein was used as the immunogen for this AMPK alpha 2 antibody.
Storage Aliquot the AMPK alpha 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Title AMPK alpha 2 Antibody / PRKAA2
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