TICAM1 Antibody, 0.4 ml

Involved in innate immunity against invading pathogens. Adapter used byTLR3andTLR4(through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteinsTBK1, TRAF6 andRIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7,NF-kappa-Band FADD respectively.