NTSR2 Antibody / Neurotensin receptor type 2, 100 ug

NTSR2 antibody detects Neurotensin receptor type 2, a G protein-coupled receptor (GPCR) that mediates the effects of the neuropeptide neurotensin on neuronal activity, pain modulation, and inflammation. The UniProt recommended name is Neurotensin receptor type 2 (NTSR2). This receptor couples to G proteins to trigger intracellular calcium mobilization and MAPK pathway activation in response to neurotensin binding.

Functionally, NTSR2 antibody identifies a 410-amino-acid seven-transmembrane receptor localized primarily in the central nervous system and peripheral tissues. NTSR2 regulates dopaminergic signaling, nociception, and gastrointestinal motility. It is distinct from NTSR1 in its lower affinity for neurotensin and its unique coupling to Gq and Gi proteins, leading to both excitatory and inhibitory cellular effects.

The NTSR2 gene is located on chromosome 2p25.1 and is highly expressed in the brainstem, hypothalamus, and spinal cord. Peripheral expression in immune cells and smooth muscle contributes to neuroimmune and cardiovascular regulation. NTSR2 activation influences neurotransmitter release, stress response, and vascular tone.

Pathologically, dysregulation of NTSR2 signaling has been associated with pain disorders, schizophrenia, addiction, and cancer progression. Its activation promotes cell migration and survival in certain tumors. Research using NTSR2 antibody supports studies in neuroscience, signal transduction, and receptor pharmacology.

NTSR2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect GPCRs and neuropeptide receptors. NSJ Bioreagents provides NTSR2 antibody reagents optimized for neurobiology, pharmacology, and signal transduction research.

Structurally, Neurotensin receptor type 2 features seven transmembrane helices typical of GPCRs, an extracellular ligand-binding region, and an intracellular tail that interacts with G proteins and arrestins. This antibody enables investigation of NTSR2's regulatory role in neurotransmission and cellular signaling.