IRGQ Antibody / Immunity-related GTPase family Q protein, 100 ug

IRGQ antibody detects Immunity-related GTPase family Q protein, a dynamin-like GTPase that participates in vesicular trafficking, membrane remodeling, and host defense mechanisms. The UniProt recommended name is Immunity-related GTPase family Q protein (IRGQ). This enzyme belongs to the immunity-related GTPase (IRG) family, known for regulating intracellular pathogen resistance and organelle dynamics in immune cells.

Functionally, IRGQ antibody identifies a 409-amino-acid GTP-binding protein localized mainly to the endoplasmic reticulum and Golgi apparatus. IRGQ hydrolyzes GTP to drive conformational changes that remodel intracellular membranes during immune activation and stress response. It is induced by interferon signaling and contributes to vesicle trafficking between endoplasmic reticulum and Golgi compartments.

The IRGQ gene is located on chromosome 19q13.33 and is expressed in immune-related tissues such as spleen, liver, and macrophages. Through its role in intracellular trafficking and vesicle fusion, IRGQ coordinates membrane remodeling events necessary for protein secretion and immune signaling.

Pathologically, IRGQ dysregulation has been associated with inflammatory and infectious diseases. Reduced IRGQ activity may impair vesicle transport, while overactivation can affect Golgi organization and cytokine secretion. Research using IRGQ antibody supports studies in GTPase biology, membrane dynamics, and immune regulation.

IRGQ antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect small GTPases and membrane-associated enzymes. NSJ Bioreagents provides IRGQ antibody reagents optimized for cellular trafficking, immune function, and molecular signaling research.

Structurally, Immunity-related GTPase family Q protein features conserved GTP-binding motifs (P-loop, switch I and II regions) and a C-terminal amphipathic helix that mediates membrane association. This antibody facilitates detailed study of IRGQ's GTPase-dependent mechanisms in host defense and vesicular transport.