SPINK4 Antibody / Serine peptidase inhibitor Kazal-type 4, 100 ug

SPINK4 antibody detects Serine peptidase inhibitor Kazal-type 4, a secreted protease inhibitor that regulates intestinal mucosal protection and epithelial homeostasis. The UniProt recommended name is Serine peptidase inhibitor Kazal-type 4 (SPINK4). This small protein is part of the Kazal-type serine protease inhibitor family and functions as a local regulator of proteolytic activity in gastrointestinal tissues.

Functionally, SPINK4 antibody identifies a 86-amino-acid protein predominantly expressed in goblet cells of the small and large intestine. SPINK4 binds and inhibits trypsin-like proteases, preventing excessive proteolysis in the mucosal environment. It contributes to epithelial integrity and immune defense by maintaining the protective mucus barrier.

The SPINK4 gene is located on chromosome 9p13.3 and is expressed specifically in intestinal and colonic mucosa. Its expression is upregulated during inflammation and epithelial injury, reflecting its protective and regulatory role in the gut.

Pathologically, elevated SPINK4 levels have been reported in colorectal cancer, inflammatory bowel disease, and gastrointestinal infections. It is a potential biomarker for epithelial stress and differentiation states in intestinal disorders. Research using SPINK4 antibody supports studies in mucosal immunology, epithelial biology, and cancer biomarker discovery.

SPINK4 antibody is validated for western blotting, ELISA, and immunohistochemistry to detect secreted protease inhibitors. NSJ Bioreagents provides SPINK4 antibody reagents optimized for research in digestive physiology, protease regulation, and epithelial pathology.

Structurally, Serine peptidase inhibitor Kazal-type 4 consists of a single Kazal inhibitory domain stabilized by disulfide bonds, which confers high affinity for target proteases. This antibody enables investigation of SPINK4's function in mucosal protection and intestinal homeostasis.