Translin Antibody / TSN, 100 ug

Translin antibody detects Translin, a highly conserved RNA and DNA-binding protein encoded by the TSN gene located on chromosome 2q11.2. Translin functions as part of the RNA processing and transport machinery, forming a complex with Trax (TSNAX) to create the C3PO (component 3 promoter of RNA-induced silencing complex) ribonuclease. This complex plays a key role in the RNA interference (RNAi) pathway by promoting the removal of passenger strands from small interfering RNAs (siRNAs), thereby facilitating gene silencing. Translin is ubiquitously expressed, with high levels found in neurons, testes, and lymphoid tissues where RNA transport and regulation are crucial.

Structurally, Translin assembles into an octameric ring that binds nucleic acids in a sequence-independent manner. It contains a central RNA/DNA-binding domain and regions that mediate oligomerization and association with Trax. Together, Translin and Trax form the C3PO complex, which promotes RNA-induced silencing by accelerating siRNA duplex unwinding. Translin belongs to the Translin family of RNA-binding proteins that regulate post-transcriptional processes across multiple tissues.

Functionally, Translin acts in mRNA transport, localization, and stabilization. In neurons, it regulates axonal mRNA transport and local translation critical for synaptic plasticity. It also participates in DNA double-strand break repair and chromosomal translocation control, linking RNA metabolism to genome maintenance. Through the C3PO complex, Translin contributes to RNAi efficiency and microRNA (miRNA) processing, ensuring proper post-transcriptional gene regulation. Known binding partners include TSNAX (Trax), AGO2, and Dicer, all involved in RNA interference and processing.

Translin expression is developmentally regulated, peaking during neuronal maturation and spermatogenesis. In germ cells, it contributes to mRNA trafficking essential for gametogenesis. In immune cells, it regulates cytokine mRNA stability and turnover. Dysregulation of Translin has been linked to neurodevelopmental disorders and cancers, where aberrant RNA regulation and chromosomal rearrangements contribute to disease progression. Pathway associations include RNA transport, RNA interference, and DNA damage repair signaling.

The Translin antibody from NSJ Bioreagents is a valuable reagent for studying RNA-binding proteins, post-transcriptional gene regulation, and the RNAi machinery.