RXFP1 Antibody / Relaxin receptor 1, 100ug

RXFP1 antibody targets Relaxin receptor 1, encoded by the RXFP1 gene. Relaxin receptor 1 is a G protein-coupled receptor that serves as the primary receptor for the peptide hormone relaxin. RXFP1 is localized at the cell membrane and initiates intracellular signaling cascades in response to ligand binding, playing key roles in tissue remodeling, vasodilation, and reproductive physiology. Unlike classical GPCRs, RXFP1 has unique structural features that enable coupling to multiple signaling pathways.<br><br>Functionally, Relaxin receptor 1 mediates the biological effects of relaxin by activating signaling pathways that include cyclic AMP production, nitric oxide signaling, and downstream kinase activation. Through these pathways, RXFP1 regulates extracellular matrix turnover, collagen remodeling, and smooth muscle relaxation. A RXFP1 antibody supports studies focused on hormone receptor signaling, tissue remodeling, and GPCR-mediated cellular responses.<br><br>RXFP1 is expressed in a range of tissues, including reproductive organs, cardiovascular tissues, and fibroblast-rich environments. Its expression pattern reflects its involvement in processes such as pregnancy-associated tissue adaptation, vascular compliance, and organ fibrosis regulation. RXFP1 localization at the plasma membrane enables rapid responsiveness to circulating relaxin and related ligands.<br><br>From a disease-relevance perspective, Relaxin receptor 1 has been investigated in cardiovascular disease, fibrosis, and reproductive disorders. Altered RXFP1 expression or signaling has been associated with pathological fibrosis, impaired vascular function, and abnormal tissue remodeling. These findings have positioned RXFP1 as a protein of interest in studies examining therapeutic modulation of relaxin signaling pathways.<br><br>At the molecular level, Relaxin receptor 1 contains conserved transmembrane domains characteristic of GPCRs, along with extracellular regions involved in ligand recognition. Receptor trafficking, ligand binding state, and post-translational modifications can influence its apparent behavior in biochemical assays without altering the primary amino acid sequence. RXFP1 antibody reagents support research applications focused on GPCR biology, hormone signaling, and disease-associated tissue remodeling, with NSJ Bioreagents providing reagents intended for research use.

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