PEX14 Antibody / Peroxisomal biogenesis factor 14, 100ug

PEX14 antibody targets Peroxisomal biogenesis factor 14, encoded by the PEX14 gene. Peroxisomal biogenesis factor 14 is an integral peroxisomal membrane protein that functions as a core docking component of the peroxisomal matrix protein import machinery. It serves as a binding site for cytosolic import receptors, including PEX5, enabling delivery of peroxisomal targeting signal-containing proteins to the peroxisome membrane.<br><br>Functionally, Peroxisomal biogenesis factor 14 acts as a central scaffold within the peroxisomal translocation complex. By interacting directly with PEX5-cargo complexes, PEX14 facilitates the initial stages of matrix protein import and coordinates assembly of the transient import pore. A PEX14 antibody supports studies focused on peroxisomal protein trafficking, membrane-associated import mechanisms, and organelle maintenance.<br><br>PEX14 is localized predominantly to the peroxisomal membrane, distinguishing it from mobile import receptors that shuttle between compartments. Its membrane-embedded position allows it to organize interactions between cytosolic receptors and other peroxins required for translocation. Through this role, Peroxisomal biogenesis factor 14 contributes to efficient import of enzymes essential for peroxisomal metabolic pathways, including lipid oxidation and redox regulation.<br><br>From a disease-related perspective, disruption of PEX14 function impairs peroxisomal matrix protein import and has been linked to peroxisome biogenesis disorders. Loss of functional PEX14 compromises peroxisomal enzyme content and organelle activity, leading to widespread metabolic consequences. These findings underscore the importance of PEX14 as a structural and functional hub in peroxisome assembly and maintenance.<br><br>At the molecular level, Peroxisomal biogenesis factor 14 contains conserved domains that mediate interactions with import receptors and other peroxisomal membrane proteins. Its apparent behavior in biochemical assays reflects its membrane-associated nature and interaction state rather than changes in protein size or sequence. PEX14 antibody reagents enable investigation of peroxisomal membrane organization and protein import pathways, with NSJ Bioreagents providing reagents intended for research use.

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