CDK-activating kinases (CAKs) are multisubunit proteins that phosphorylate and thus activate certain cyclin-dependent protein kinases in the regulation of cell cycle progression. The Cyclin dependent kinase7 gene is mapped to chromosome 2p15-cen. Cdk7 functions in both cyclin binding and T-loop phosphorylation and that these 2 steps of Cdk1 activation are mutually dependent.
