Zebrafish Nol10 Antibody / Nucleolar protein 10, 100 ug

By immunoprecipitation of human AATF it was discovered that AATF forms a salt-stable protein complex together with neuroguidin (NGDN) and NOL10 and demonstrated that the AATF-NGDN-NOL10 (ANN) complex functions in ribosome biogenesis. All three ANN complex members localize to nucleoli and display a mutual dependence with respect to protein stability. Mapping of protein-protein interaction domains revealed the importance of both the evolutionary conserved WD40 repeats in NOL10 and the UTP3/SAS10 domain in NGDN for complex formation.