Zebrafish Polr2a Antibody / DNA-directed RNA polymerase subunit, 100 ug

Polr2a (RNA polymerase II subunit alpha) is a critical protein component of RNA polymerase II, the enzyme responsible for transcribing protein-coding genes into messenger RNA (mRNA) in eukaryotic cells. Polr2a is a core subunit of the RNA polymerase II complex, which plays a pivotal role in gene expression and transcription regulation. The protein is involved in the initiation, elongation, and termination of transcription, as well as the processing of nascent RNA transcripts.

In zebrafish, Polr2a is an ortholog of the human POLR2A gene. The zebrafish and human Polr2a proteins are highly conserved, indicating a similar functional role in transcriptional regulation across species. Both proteins are integral parts of the RNA polymerase II complex, ensuring the synthesis of mRNA and playing a vital role in cellular gene expression.

Polr2a is widely expressed across zebrafish tissues, including the brain, heart, and muscle, reflecting its essential function in general cellular processes and development. It is crucial for the transcription of protein-coding genes during early embryonic development, cell differentiation, and growth. The proper functioning of Polr2a is required for cell cycle progression, cellular maintenance, and response to environmental signals.

Zebrafish Polr2a has isoforms, which may exhibit variations in their expression patterns and functional properties. These isoforms could be related to developmental stages and tissue-specific functions, helping to fine-tune transcriptional regulation during embryogenesis and tissue-specific differentiation. The presence of isoforms may also suggest a level of functional specialization in response to cellular demands during development and environmental adaptation.

Given its role in transcription regulation, gene expression, and embryonic development, zebrafish Polr2a is a vital protein for studying gene regulation, transcriptional control, and developmental biology. It also provides a useful model for investigating transcriptional dysregulation in diseases such as cancer, neurodegenerative diseases, and genetic disorders related to gene expression abnormalities.