NSJ Bioreagents
SKU(재고 관리 코드):V5688-20UG
TIGIT Antibody / VSTM3 / VSIG9, 20 ug
TIGIT Antibody / VSTM3 / VSIG9, 20 ug
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TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR), causing increased IL10 secretion, decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells, as well as peripheral memory and regulatory CD4+ T cells. At the protein level, it is upregulated following the activation of these cells. Functionally, TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
Specifications
| Catalog No | V5688-20UG |
|---|---|
| Family | Primary antibody |
| Qty | 20 ug |
| Formulation | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Clone | TIGIT/3018 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2c, kappa |
| Species Reactivity | Human |
| Application | ELISA |
| Application Details | ELISA |
| Application Note | Optimal dilution of the TIGIT antibody should be determined by the researcher. |
| Status | Available |
| PDF Link | Product Data Sheet (PDF) |
| Limitation | This TIGIT antibody is available for research use only. |
| Uniprot # | Q495A1 |
| Purity | Protein A/G affinity |
| Immunogen | A portion of amino acids 22-141 from human TIGIT protein was used as the immunogen for the TIGIT antibody. |
| Storage | Aliquot the TIGIT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Localization | Cell membrane, Cell surface |
| Title | TIGIT Antibody / VSTM3 / VSIG9 |