TIGIT Antibody / T-cell immunoreceptor with Ig and ITIM domains, 100ug

TIGIT antibody targets T-cell immunoreceptor with Ig and ITIM domains, an immune checkpoint receptor encoded by the TIGIT gene and expressed primarily on activated T cells, regulatory T cells, and natural killer cells. TIGIT is a member of the immunoglobulin superfamily and functions as an inhibitory receptor that modulates immune activation by transmitting suppressive signals upon ligand engagement. Through this role, TIGIT contributes to the fine-tuning of immune responses and maintenance of peripheral tolerance.<br><br>TIGIT is localized to the cell surface, where it interacts with poliovirus receptor family ligands such as CD155 and CD112 expressed on antigen-presenting cells and tumor cells. Ligand binding triggers intracellular signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) domain, leading to attenuation of T-cell receptor signaling and reduced cytokine production. TIGIT antibody detection is therefore relevant for studying immune checkpoint pathways and cell-cell interactions within immune microenvironments.<br><br>Functionally, TIGIT suppresses effector T-cell proliferation and cytotoxic activity while enhancing the immunosuppressive function of regulatory T cells. In natural killer cells, TIGIT engagement reduces cytolytic activity and interferon gamma production. These coordinated effects position TIGIT as a key regulator of immune exhaustion and tolerance. TIGIT antibody reagents support research into immune regulation, checkpoint signaling, and adaptive immune balance.<br><br>Aberrant TIGIT expression has been observed in chronic infections, autoimmune disorders, and multiple cancer types. Elevated TIGIT levels are frequently associated with T-cell exhaustion within tumor microenvironments, where TIGIT contributes to immune evasion by malignant cells. As a result, TIGIT has emerged as an important target in immuno-oncology research, particularly in combination with other checkpoint pathways such as PD-1 and CTLA-4. These associations underscore the relevance of TIGIT antibody-based detection in studies of tumor immunity and immune dysfunction.<br><br>Clone TIGIT/3033 is designed to recognize T-cell immunoreceptor with Ig and ITIM domains in research applications. TIGIT antibody reagents are suitable for detecting protein expression and localization in immune cell populations and tissue samples, supporting investigations into immune checkpoint biology, T-cell regulation, and disease-associated immune suppression.<br><br>For broader analysis of TIGIT as an immune checkpoint marker across applications, see our <a href=../tds/tigit-antibody-vstm3-vsig9-tigit3017-v7583>TIGIT antibody TIGIT/3017</a>.

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