ESR2 Antibody / Estrogen Receptor beta, 20ug

Estrogen receptor 2 Antibody targets Estrogen receptor 2, a nuclear hormone receptor encoded by the ESR2 gene and widely known as estrogen receptor beta or ER beta. Estrogen receptor 2 functions as a ligand-activated transcriptional regulator that mediates cellular responses to estrogen signaling, often in a manner distinct from Estrogen receptor 1. Through regulation of gene expression, estrogen receptor beta contributes to tissue-specific estrogen responsiveness and transcriptional balance in hormone-regulated systems.<br><br>Estrogen receptor 2 is primarily localized to the nucleus, where ER beta binds estrogen response elements and interacts with transcriptional co-regulators to modulate gene expression. In contrast to estrogen receptor alpha, estrogen receptor beta is frequently associated with modulatory or context-dependent transcriptional effects, influencing cellular differentiation, growth restraint, and signaling integration. Estrogen receptor 2 Antibody detection is therefore useful for studying nuclear receptor signaling diversity and estrogen-dependent transcriptional regulation.<br><br>Functionally, Estrogen receptor 2 regulates genes involved in reproductive biology, central nervous system function, immune modulation, and metabolic regulation. ER beta expression is prominent in tissues such as ovary, prostate, lung, brain, and immune-associated cell populations, where estrogen signaling plays nuanced regulatory roles. Estrogen receptor beta activity often counterbalances or complements ER alpha signaling, highlighting its importance in maintaining estrogen signaling equilibrium.<br><br>Altered expression or signaling of Estrogen receptor 2 has been implicated in disease-associated changes in hormone responsiveness. Dysregulation of ER beta-mediated transcriptional programs can contribute to abnormal cellular behavior, including altered proliferation, differentiation, and inflammatory responses. Studying Estrogen receptor 2 provides insight into estrogen signaling pathways that extend beyond classical estrogen receptor alpha-driven mechanisms.<br><br>Clone ESR2/6661 is designed to recognize Estrogen receptor 2 in research applications. Estrogen receptor 2 Antibody reagents are suitable for detecting nuclear ER beta expression and supporting studies focused on estrogen signaling diversity, transcriptional regulation, and hormone-responsive gene expression programs.<br><br>For comprehensive detection of Estrogen receptor beta across hormone signaling and tumor biology studies, see our <a href=../tds/estrogen-receptor-beta-antibody-erb455-v2115>Estrogen Receptor beta antibody (clone ERb455)</a>.

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