FABP2 Antibody / I-FABP, 20ug

Intestinal fatty acid-binding protein is a small cytosolic lipid chaperone encoded by the FABP2 gene and is highly enriched in absorptive epithelial cells of the small intestine. This protein is commonly referred to in the literature as intestinal FABP, I-FABP, and fatty acid-binding protein 2, reflecting its tissue specificity and functional role in intestinal lipid handling. Intestinal fatty acid-binding protein antibody reagents are widely used to study enterocyte biology, epithelial integrity, and lipid transport processes within the gastrointestinal tract.<br><br>Intestinal fatty acid-binding protein belongs to the fatty acid-binding protein family, a group of low molecular weight proteins that bind long-chain fatty acids and other hydrophobic ligands within the cytoplasm. Within enterocytes, intestinal FABP facilitates intracellular trafficking of dietary fatty acids from the apical membrane toward sites of metabolism, esterification, and lipoprotein assembly. Its cytoplasmic localization and high abundance in the small intestine make I-FABP a well-established marker of intestinal epithelial cells and enterocyte differentiation.<br><br>Expression of intestinal fatty acid-binding protein is largely restricted to the small intestine, with strongest levels observed in mature enterocytes lining the villi. This tissue-restricted pattern has led to frequent use of intestinal FABP antibody reagents in studies of intestinal injury, epithelial turnover, and barrier dysfunction. Elevated release of I-FABP into circulation has been reported in conditions involving enterocyte damage, supporting its relevance in gastrointestinal disease research and biomarker development.<br><br>At the functional level, intestinal fatty acid-binding protein participates in fatty acid uptake, buffering, and intracellular transport, thereby contributing to efficient lipid absorption and metabolic homeostasis. By binding long-chain fatty acids, FABP2 helps regulate lipid signaling pathways and protects cells from lipotoxic effects. These properties have driven continued interest in intestinal FABP as a molecular readout of enterocyte function and metabolic status.<br><br>The Intestinal fatty acid-binding protein antibody clone FABP2/6936 is designed to recognize FABP2 in research applications. This monoclonal antibody enables detection of I-FABP expression in intestinal tissues and related experimental models, supporting studies focused on gastrointestinal physiology, epithelial biology, and lipid metabolism.<br><br>Researchers seeking a broadly validated FABP2 antibody for intestinal epithelial biology and lipid absorption studies may also be interested in our HuProt-validated <a href=../tds/fabp2-antibody-fatty-acid-binding-protein-2-fabp2-6344-v5886>FABP2 antibody clone FABP2/6344</a>, supported by western blot, immunohistochemistry, and protein microarray specificity data.

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