FCGR1A Antibody / High affinity immunoglobulin gamma Fc receptor I, 20ug

Fc gamma receptor I (also known as High affinity immunoglobulin gamma Fc receptor I) is a cell surface immunoreceptor encoded by the FCGR1A gene and is commonly referred to as CD64 in the immunology literature. FCGR1A is a member of the Fc gamma receptor family and is distinguished by its high affinity for monomeric IgG, allowing it to bind circulating immunoglobulin under physiological conditions. The FCGR1A antibody is widely used to study immune cell activation, antibody-mediated phagocytosis, and inflammatory signaling pathways.<br><br>FCGR1A is predominantly expressed on cells of the myeloid lineage, including monocytes, macrophages, and activated dendritic cells. Expression levels are dynamically regulated by inflammatory cytokines such as interferon-gamma, which strongly upregulates CD64 during immune activation. This inducible expression pattern makes FCGR1A a valuable marker for immune activation states and inflammatory responses. In tissues, FCGR1A localizes to the plasma membrane, where it functions as a receptor for IgG-opsonized targets and immune complexes.<br><br>Structurally, Fc gamma receptor I contains three extracellular immunoglobulin-like domains, distinguishing it from lower-affinity Fc gamma receptors that contain only two such domains. This structural feature underlies its high-affinity IgG binding capability. Upon ligand engagement, FCGR1A associates with the common Fc receptor gamma chain, which contains immunoreceptor tyrosine-based activation motifs that initiate downstream signaling cascades leading to phagocytosis, cytokine release, and antigen presentation.<br><br>Functionally, FCGR1A plays a central role in innate and adaptive immune crosstalk. By mediating uptake of IgG-coated pathogens or cellular debris, it contributes to antigen processing and presentation, linking humoral immunity to cellular immune responses. Altered FCGR1A expression has been reported in autoimmune diseases, chronic inflammatory disorders, infectious diseases, and hematologic malignancies. Because CD64 expression increases on activated monocytes and macrophages, FCGR1A antibody reagents are frequently used to assess immune activation status in research settings.<br><br>The FCGR1A antibody clone FCGR1A/7499 is designed to recognize Fc gamma receptor I in research applications. Clone FCGR1A/7499 provides a useful tool for investigating CD64 expression patterns, immune cell phenotyping, and receptor distribution in normal and disease-associated tissues.<br><br>Researchers studying Fc receptor signaling, monocyte activation, and antibody-dependent immune responses may also benefit from the <a href=../tds/cd64-antibody-fcgr1a-101-v7768>CD64 Antibody / High-Affinity Fc Gamma Receptor</a> page featuring the widely published clone 10.1 and flow cytometry validation in PBMC immune cell populations.

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