FOLR1 Antibody / Folate receptor 1, 20ug

FR alpha antibody is used to study Folate receptor alpha, a high-affinity folate binding protein that mediates receptor-dependent folate uptake at the cell surface. Folate receptor alpha is encoded by the FOLR1 gene and is anchored to the plasma membrane via a glycosylphosphatidylinositol linkage. This membrane association allows the receptor to concentrate folate at the cell surface and internalize it through endocytic pathways, supporting cellular processes that depend on one-carbon metabolism and nucleotide biosynthesis.<br><br>Folate receptor alpha is commonly referred to as FR alpha in the literature, particularly in studies focused on epithelial transport and cancer-associated folate metabolism. FR alpha expression is normally restricted to select epithelial tissues, where it localizes to the apical surface of polarized cells. This spatially regulated expression distinguishes FR alpha from other folate transport systems and has made it a useful marker for studying epithelial polarity, membrane trafficking, and nutrient uptake mechanisms. Use of a FR alpha antibody enables detailed examination of FR alpha distribution in tissue and cell-based models.<br><br>At the functional level, FR alpha facilitates uptake of folate by binding extracellular folate with high affinity and delivering it to intracellular compartments following endocytosis. This pathway operates independently of reduced folate carriers and is particularly important in environments where folate availability is limited. Studies using FOLR1 antibody have contributed to understanding how FR alpha-mediated transport supports proliferation and survival in rapidly dividing epithelial cells.<br><br>Aberrant expression of FR alpha has been widely documented in epithelial malignancies, most notably in ovarian carcinoma but also in subsets of lung, breast, and endometrial cancers. In these contexts, elevated FR alpha expression reflects altered metabolic demands and changes in epithelial differentiation. Detection of FR alpha using a FOLR1 antibody supports research into tumor-associated folate metabolism, epithelial lineage markers, and metabolic adaptation in cancer cells.<br><br>FR alpha antibody (clone FOLR1/13424R) is designed to detect Folate receptor alpha in research applications. Evaluation of FR alpha expression provides insight into folate transport pathways, epithelial cell organization, and disease-associated changes in nutrient uptake. Overall, Folate receptor alpha remains a key protein linking membrane transport, epithelial biology, and metabolic regulation.

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