KRT10 Antibody / Type I cytoskeletal keratin 10, 100ug

Suprabasal keratin antibody targets Cytokeratin 10, a differentiation-associated type I intermediate filament protein encoded by the KRT10 gene and widely recognized as a hallmark marker of suprabasal keratinocyte maturation. Cytokeratin 10, also referred to as Keratin 10 or CK10 in the literature, is selectively induced as epidermal keratinocytes withdraw from the basal proliferative compartment and initiate terminal differentiation. At the cellular level, Cytokeratin 10 localizes to the cytoplasm, where it pairs predominantly with Keratin 1 to assemble robust intermediate filament networks that support epidermal structure and barrier formation.<br><br>Cytokeratin 10 expression is tightly restricted to suprabasal layers of stratified squamous epithelia, including the epidermis and related epithelial surfaces. This sharply defined distribution distinguishes suprabasal keratinocytes from basal progenitor cells, which instead express basal keratins such as Keratin 5 and Keratin 14. Because of this clear compartmentalization, a suprabasal keratin antibody provides valuable insight into epithelial differentiation status and stratification integrity. Detection of Cytokeratin 10 is therefore widely used in studies examining epidermal maturation, keratinocyte lineage commitment, and tissue architecture in normal and diseased states.<br><br>In epithelial disease research, altered Cytokeratin 10 expression is frequently associated with disrupted differentiation programs. Reduced or absent CK10 expression is observed in hyperproliferative skin disorders, inflammatory dermatoses, and poorly differentiated squamous lesions, reflecting loss of terminal differentiation. In contrast, retained Cytokeratin 10 expression is often seen in well-differentiated squamous epithelia and selected squamous cell carcinomas, where it marks differentiated tumor cell populations. These expression patterns make suprabasal keratin antibody reagents useful for investigating squamous differentiation and epithelial remodeling.<br><br>At the molecular level, Cytokeratin 10 belongs to the acidic type I keratin family and contains conserved alpha-helical domains required for filament assembly and cytoskeletal stability. Its expression is regulated by calcium-dependent signaling and differentiation-associated transcriptional pathways. Clone KRT10/9605R is designed to recognize Cytokeratin 10 and supports research applications focused on epidermal biology, squamous differentiation, and suprabasal epithelial identity.

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