Cytokeratin 14 Antibody / CK14 / KRT14, 100ug

KRT14 Antibody recognizes Keratin 14, also known as Cytokeratin 14 (KRT14), a type I intermediate filament protein that serves as a defining structural marker of basal cells in stratified squamous epithelia. Keratin 14 is a cytoplasmic protein that forms obligate heterodimers with type II keratins, most prominently Keratin 5, to assemble intermediate filaments that provide mechanical strength, cellular integrity, and resistance to physical stress in epithelial tissues. KRT14 Antibody is widely used in research contexts to identify basal squamous epithelial cells and is commonly referred to as Cytokeratin 14 antibody or CK14 antibody in the literature.<br><br>Cytokeratin 14 expression is characteristically confined to the basal layer of stratified squamous epithelia, including epidermis, oral mucosa, esophagus, cervix, and other squamous-lined tissues. In these tissues, KRT14-positive basal cells represent the proliferative compartment responsible for epithelial renewal and regeneration. As basal cells differentiate and migrate toward suprabasal layers, Cytokeratin 14 expression decreases and is replaced by differentiation-associated keratins such as Cytokeratin 13 or Cytokeratin 10. This sharply defined basal localization makes KRT14 Antibody particularly useful for distinguishing basal progenitor cells from differentiated squamous epithelial populations.<br><br>Altered Cytokeratin 14 expression has been documented in a range of pathological conditions. Expansion of KRT14 expression beyond the basal layer is frequently observed in epithelial hyperplasia, dysplasia, and squamous cell carcinoma, reflecting disrupted differentiation programs and abnormal epithelial architecture. For this reason, Cytokeratin 14 antibody staining patterns are commonly evaluated in research studies focused on basal cell biology, squamous lineage commitment, and epithelial tumor progression.<br><br>At the cellular level, Cytokeratin 14 contributes to cytoskeletal organization and plays a role in anchoring basal epithelial cells to the basement membrane through interactions with desmosomes and hemidesmosomes. Its basal cell-restricted expression makes KRT14 Antibody a useful tool for studying epithelial stratification, basal cell dynamics, and squamous tissue organization. The KRT14 Antibody (clone KRT14/6961) is designed to detect Cytokeratin 14 expression in research applications where identification of basal squamous epithelial cells is required.

Specifications