MBP Antibody for IHC / Myelin basic protein, 20ug

Myelin Basic Protein (MBP) is a major structural component of the myelin sheath in the central nervous system, where it plays a critical role in myelin compaction, axonal insulation, and maintenance of white matter integrity. MBP Antibody for IHC is optimized for detection of myelin-associated structures in formalin-fixed, paraffin-embedded tissues, enabling detailed visualization of neural architecture and white matter distribution in histological sections.<br><br>MBP antibody, also known as Myelin Basic Protein antibody, is widely used in immunohistochemistry as a highly specific marker of oligodendrocyte-derived myelin. MBP is strongly expressed in central nervous system white matter, including cerebellar and cerebral tracts, where it localizes along myelinated axons and highlights fiber-rich regions with distinct morphology. Expression is minimal in gray matter and largely absent in non-neural tissues, supporting its use as a lineage-restricted marker for myelinated structures and central nervous system origin.<br><br>Clone MSVA-390R is a recombinant rabbit monoclonal antibody developed for high-affinity and reproducible detection of MBP in FFPE samples. This clone produces strong, well-defined staining of myelinated fibers with low background, allowing clear distinction between white matter and surrounding tissue compartments. In Tissue Microarray (TMA) analysis, MBP Antibody for IHC demonstrates highly consistent staining across multiple neural tissue cores, enabling reliable comparison of myelin distribution and density across samples.<br><br>In normal tissue microarrays, MBP expression is prominently detected in white matter regions of the cerebellum and cerebrum, where dense networks of myelinated axons generate strong HRP-DAB brown signal. Gray matter regions show comparatively reduced staining, reflecting lower myelin content. Non-neural tissues including epithelial, glandular, and stromal compartments are largely negative, reinforcing the specificity of MBP as a central nervous system myelin marker and supporting accurate tissue classification in complex samples.<br><br>In cancer tissue microarrays, MBP staining is generally absent in non-neural malignancies such as carcinomas and mesenchymal tumors, consistent with its restricted expression profile. This negative staining pattern provides a useful contrast when evaluating tumors of uncertain origin and supports the use of MBP Antibody for IHC in identifying central nervous system-derived lesions or confirming lack of neural differentiation in peripheral tumors.<br><br>The robust and reproducible performance of clone MSVA-390R in TMA-based immunohistochemistry supports its application in neuropathology, neurodevelopmental studies, and research on demyelinating diseases such as multiple sclerosis. MBP Antibody for IHC enables consistent visualization of myelin architecture across FFPE tissues and is well suited for comparative tissue analysis, disease modeling, and evaluation of white matter integrity.<br><br>This antibody is also part of a broader collection of <a href='/ihc-antibodies-tissue-microarray-validated.html'>IHC antibodies validated by tissue microarray analysis</a>, supporting consistent staining across normal and cancer tissues.

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