MUC4 Antibody / Mucin 4, 100ug

Sialomucin Complex Subunit 4 antibody targets Mucin-4, a large transmembrane glycoprotein encoded by the human MUC4 gene and a member of the membrane-bound mucin family. Sialomucin complex subunit 4 refers to the membrane-associated component of the heterodimeric MUC4 complex that was originally characterized as part of the ascites sialoglycoprotein system. In the literature, Sialomucin Complex Subunit 4 antibody, MUC4 antibody, and Mucin-4 antibody are used to describe detection of the same epithelial mucin protein that plays critical roles in barrier function and tumor biology.<br><br>MUC4 is synthesized as a high molecular weight precursor that undergoes proteolytic processing into two subunits that remain non-covalently associated at the cell surface. These are historically described as ASGP-1 and ASGP-2, with Sialomucin complex subunit 4 corresponding to the membrane-spanning ASGP-2 component. The extracellular region contains heavily O-glycosylated tandem repeat domains that contribute to mucosal protection, while the membrane-associated subunit contains epidermal growth factor-like domains, a transmembrane region, and a cytoplasmic tail involved in intracellular signaling. Sialomucin Complex Subunit 4 antibody is therefore valuable for investigating epithelial differentiation and membrane-associated signaling pathways.<br><br>In normal tissues, Mucin-4 expression is largely restricted to glandular and ductal epithelial cells of the respiratory, gastrointestinal, and genitourinary tracts. During malignant transformation, MUC4 expression frequently becomes upregulated and loses apical polarity, contributing to altered cell adhesion, increased tumor cell survival, and enhanced metastatic potential. Elevated MUC4 expression has been documented in pancreatic, breast, lung, ovarian, gastric, and colorectal carcinomas.<br><br>Mucin-4 has been shown to interact with receptor tyrosine kinases such as ERBB2, modulating downstream pathways that regulate proliferation and resistance to apoptosis. A Sialomucin Complex Subunit 4 antibody such as clone MUC4/8660R is suitable for detecting MUC4 expression in epithelial tissues and tumor biology research applications.

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